THE EFFECT OF HIGH (200μG/KG/MIN) VERSUS STANDARD (140μG/KG/MIN) ADENOSINE DOSE IN PATIENTS WITH PD/PA VARIATION DURING STANDARD FFR ASSESSMENT

the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation

in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.

A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia.

We conducted a phase 3 randomized trial comparing 2 different doses of daunorubicin as induction chemotherapy in young adults (60 years of age or younger) with acute myeloid leukemia (AML). Of 383 patients who were analyzed, 189 received standard-dose daunorubicin (SD-DN, 45 mg/m² per day times 3 days) and 194 received high-dose daunorubicin (HD-DN, 90 mg/m² per day times 3 days) in addition to...

530Disease Modulation in Older Adults Vaccinated with High-Dose Versus Standard-Dose Influenza Vaccine

Background. High-dose inactivated influenza vaccine (IIV-HD) induces higher antibody responses and provides improved protection against influenza illness compared to a standard-dose vaccine (IIV-SD) in older adults. We evaluated its impact on disease modulation. Methods. A multicenter, randomized, double-blind, active-controlled trial compared IIV-HD (60 μg of hemagglutinin [HA] per strain) to ...

Pharmacokinetics and tolerability of a higher rifampin dose versus the standard dose in pulmonary tuberculosis patients.

Rifampin is a key drug for tuberculosis (TB) treatment. The available data suggest that the currently applied 10-mg/kg of body weight dose of rifampin may be too low and that increasing the dose may shorten the treatment duration. A double-blind randomized phase II clinical trial was performed to investigate the effect of a higher dose of rifampin in terms of pharmacokinetics and tolerability. ...

Pharmacokinetics and Tolerability of a Higher Rifampicin Dose versus the Standard Dose in Pulmonary Tuberculosis Patients